Back to Search
Start Over
Design, synthesis and biological activity evaluation of arylpiperazine derivatives for the treatment of neuropathic pain.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2011 Jul 07; Vol. 16 (7), pp. 5785-806. Date of Electronic Publication: 2011 Jul 07. - Publication Year :
- 2011
-
Abstract
- In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-1-phenylethanone (19) exhibited potent analgesic activities in both the mice writhing and mice hot plate tests. They showed more than 70% inhibition relative to controls in the writhing test, and increased latency by 116.0% and 134.4%, respectively, in the hot plate test. Furthermore, compound 18 was also active in the models of formalin pain and neuropathic pain without sedative side effects.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 21738106
- Full Text :
- https://doi.org/10.3390/molecules16075785