Is hyperhomocysteinemia relevant in patients with celiac disease?

Authors :: Casella G
Bassotti G
Villanacci V
Di Bella C
Pagni F
Corti GL
Sabatino G
Piatti M
Baldini V
Source :: World journal of gastroenterology [World J Gastroenterol] 2011 Jun 28; Vol. 17 (24), pp. 2941-4.
Publication Year :: 2011
Abstract: Aim: To investigate whether this might be related to the presence of hyperhomocysteinemia.<br />Methods: From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years).<br />Results: Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).<br />Conclusion: The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.