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On the elucidation of the mechanism of Vinca alkaloid fluorination in superacidic medium.
- Source :
-
Organic letters [Org Lett] 2011 Aug 05; Vol. 13 (15), pp. 4116-9. Date of Electronic Publication: 2011 Jul 06. - Publication Year :
- 2011
-
Abstract
- Detailed investigations on one of the key steps of the superacidic fluorination of Vinca alkaloids that is the origin of C20' activation are reported. While two different pathways can be envisioned for the emergence of the transient secondary carbocationic intermediate, isotopic labeling experiments unambiguously revealed the involvement of a 1,2-hydride shift mechanism.<br /> (© 2011 American Chemical Society)
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 13
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 21732596
- Full Text :
- https://doi.org/10.1021/ol201637m