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A rhesus monkey model for sexual transmission of a papillomavirus isolated from a squamous cell carcinoma.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1990 Oct; Vol. 87 (20), pp. 8170-4. - Publication Year :
- 1990
-
Abstract
- Recently we molecularly cloned and characterized a papillomavirus from a lymph node metastasis of a primary penile carcinoma found in a rhesus monkey; this virus species, rhesus papillomavirus type 1 (RhPV-1), is similar to oncogenic human papillomaviruses (HPVs), such as HPV-16 or HPV-18, in that the RhPV-1 DNA was found to be integrated in the tumor cell DNA. To compare the sexual transmission and oncogenic nature of RhPV-1 with these HPVs, we undertook an extensive retrospective study of a group of rhesus monkeys whose sexual mating and offspring histories were known. These animals had mated directly with the index male mentioned above or were secondarily exposed to this virus through intermediate sexual partners. This study combines cytological, histopathological, and several complementary hybridization and DNA amplification techniques on multiple tissue samples to demonstrate the sexually transmitted nature of RhPV-1. The oncogenic potential of RhPV-1 is suggested in several of the infected animals by the presence of various degrees of neoplasia including squamous cell cancer of the cervix.
- Subjects :
- Animals
Base Sequence
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell pathology
Crosses, Genetic
DNA, Viral genetics
DNA, Viral isolation & purification
Female
Macaca mulatta
Male
Molecular Sequence Data
Oligonucleotide Probes
Papillomaviridae genetics
Pedigree
Polymerase Chain Reaction
Sexually Transmitted Diseases pathology
Tumor Virus Infections genetics
Tumor Virus Infections microbiology
Tumor Virus Infections pathology
Carcinoma, Squamous Cell microbiology
Papillomaviridae isolation & purification
Sexually Transmitted Diseases transmission
Tumor Virus Infections transmission
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 87
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 2172976
- Full Text :
- https://doi.org/10.1073/pnas.87.20.8170