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Induction of circulating monocyte chemoattractant protein-1 in women with gonadotropin-releasing hormone agonist.
- Source :
-
Journal of reproductive immunology [J Reprod Immunol] 2011 Aug; Vol. 90 (2), pp. 227-34. Date of Electronic Publication: 2011 Jul 02. - Publication Year :
- 2011
-
Abstract
- The aim of the present study was to determine the influence of acute estrogen deficiency induced by administration of a gonadotropin-releasing hormone (GnRH) agonist on circulating levels of cytokines and chemokines. Eighty-three women with uterine leiomyoma were assigned in open, parallel-group fashion to a no-treatment (control) group and a GnRH-agonist group. Serum levels of nine cytokines and chemokines as well as vascular inflammatory markers were measured. Serum levels of monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor-α (TNFα) in the GnRH-agonist group were increased significantly at 6 months. There were also significant differences in percentage changes in interleukin (IL)-6, IL8, MCP1, and macrophage inflammatory protein-1β (MIP1β) between the control and GnRH agonist groups. Soluble intercellular adhesion molecule-1 (sICAM1) and E-selectin levels showed significant increases in the GnRH agonist group at 6 months. Serum MCP1 concentrations showed weak correlations with levels of sICAM and E-selectin. We conclude that a hypo-estrogenic state due to administration of a GnRH agonist increases circulating levels of cytokines and chemokines, especially MCP1.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Female
Humans
Leiomyoma blood
Leiomyoma drug therapy
Time Factors
Uterine Neoplasms blood
Uterine Neoplasms drug therapy
Chemokine CCL2 blood
Cytokines blood
E-Selectin blood
Fertility Agents, Female administration & dosage
Gonadotropin-Releasing Hormone agonists
Intercellular Adhesion Molecule-1 blood
Leuprolide administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7603
- Volume :
- 90
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of reproductive immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21726903
- Full Text :
- https://doi.org/10.1016/j.jri.2011.04.011