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Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia.
- Source :
-
Blood cells, molecules & diseases [Blood Cells Mol Dis] 2011 Aug 15; Vol. 47 (2), pp. 125-8. Date of Electronic Publication: 2011 Jul 02. - Publication Year :
- 2011
-
Abstract
- Background: Chronic blood transfusion (CBT) is currently the standard of care for primary and secondary stroke prevention in children with sickle cell anemia (SCA). However, the effect of CBT on cerebrovascular pathology is not well known.<br />Methods: We reviewed children with SCA receiving CBT for abnormal transcranial Doppler (TCD) [n=12] or cerebrovascular accident (CVA) [n=22]. Baseline cerebral magnetic resonance imaging (MRI) and magnetic resonance angiogram (MRA) were compared with the most recent scans available for each patient and independently scored by a neuroradiologist.<br />Results: Thirty-four patients with a mean age of 6.5years at the time of baseline MRI/MRA were studied. Average elapsed time from baseline to most recent scans was 7.3years. Overall, patients experienced worsening vasculopathy, as measured by mean increases in their baseline MRI and MRA scores of +0.76 and +1.03. There was a significant difference in the mean change of MRI/MRA scores between patients who had CVA and abnormal TCD (MRI; +1.23 vs. -0.08, p=0.001 and MRA; +1.54 vs. +0.08, p=0.02). Patients with abnormal baseline MRA had worsening scores compared to those with normal baseline MRA (54% vs. 9.5%, p=0.01). Also, patients who had CVA were more likely to have an abnormal baseline MRA and worsening scores compared to abnormal TCD patients.<br />Conclusion: We show that children with CVA experience progression of cerebral vasculopathy despite CBT. In contrast, CBT for abnormal TCD confers protection against the development and/or progression of cerebral vasculopathy. This effect appears to be real given our large cohort of patients with longer follow up as compared to previous studies.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Anemia, Sickle Cell complications
Anemia, Sickle Cell diagnostic imaging
Brain metabolism
Brain pathology
Child
Child, Preschool
Cohort Studies
Female
Follow-Up Studies
Hemoglobin, Sickle analysis
Humans
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
Pediatrics
Retrospective Studies
Stroke diagnostic imaging
Stroke etiology
Stroke prevention & control
Ultrasonography, Doppler, Transcranial
Anemia, Sickle Cell therapy
Blood Transfusion methods
Brain blood supply
Cerebrovascular Circulation
Disease Progression
Stroke therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0961
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Blood cells, molecules & diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21724428
- Full Text :
- https://doi.org/10.1016/j.bcmd.2011.06.002