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Estradiol suppresses recovery of REM sleep following sleep deprivation in ovariectomized female rats.
- Source :
-
Physiology & behavior [Physiol Behav] 2011 Oct 24; Vol. 104 (5), pp. 962-71. Date of Electronic Publication: 2011 Jun 23. - Publication Year :
- 2011
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Abstract
- Sleep complaints such as insufficient sleep and insomnia are twice as prevalent in women. Symptoms of sleep disruption are often coincident with changes in the gonadal hormone profile across a women's lifespan. Data from a number of different species, including humans, non-human primates and rodents strongly implicate a role for gonadal hormones in the modulation of sleep. In female rats, increased levels of circulating estradiol increase wakefulness and reduce sleep in the dark phase. In this study, we asked whether this reduction in sleep is driven by estradiol-dependent reduction in sleep need during the dark phase by assessing sleep before and after sleep deprivation (SD). Ovariectomized rats implanted with EEG telemetry transmitters were given Silastic capsules containing either 17-β estradiol in sesame oil (E2) or sesame oil alone. After a 24-hour baseline, animals were sleep-deprived via gentle handling for the entire 12-hour light phase, and then allowed to recover. E2 treatment suppressed baseline REM sleep duration in the dark phase, but not NREM or Wake duration, within three days. While SD induced a compensatory increase in REM duration in both groups, this increase was smaller in E2-treated rats compared to oils, as measured in absolute duration as well as by relative increase over baseline. Thus, E2 suppressed REM sleep in the dark phase both before and after SD. E2 also suppressed NREM and increased waking in the early- to mid-dark phase on the day after SD. NREM delta power tracked NREM sleep before and after SD, with small hormone-dependent reductions in delta power in recovery, but not spontaneous sleep. These results demonstrate that E2 powerfully and specifically suppresses spontaneous and recovery REM sleep in the dark phase, and suggest that ovarian steroids may consolidate circadian sleep-wake rhythms.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Analysis of Variance
Animals
Electroencephalography
Electromyography
Estradiol blood
Female
Ovariectomy
Rats
Rats, Sprague-Dawley
Sleep Deprivation drug therapy
Time Factors
Wakefulness
Estradiol administration & dosage
Estrogens administration & dosage
Recovery of Function drug effects
Sleep Deprivation physiopathology
Sleep, REM drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-507X
- Volume :
- 104
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Physiology & behavior
- Publication Type :
- Academic Journal
- Accession number :
- 21722658
- Full Text :
- https://doi.org/10.1016/j.physbeh.2011.06.016