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Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2011 Dec; Vol. 26 (12), pp. 2179-84. Date of Electronic Publication: 2011 Jul 01. - Publication Year :
- 2011
-
Abstract
- Metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) degrade type IV collagen, and represent important tissue remodeling enzymes in several kidney disorders. In this study, we measured urinary levels of MMP-2, MMP-9, and the tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in patients with steroid-sensitive nephrotic syndrome (SSNS, n = 18, median age 5) and focal segmental glomerulosclerosis (FSGS, n = 16, median age 15). We found that urinary concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were significantly elevated in FSGS patients as compared to SSNS in both relapse and remission (p < 0.002). Furthermore, urinary levels of these enzymes are increased early on in the FSGS disease process (chronic kidney disease stages 1 and 2). The findings from this pilot study suggest that MMPs and TIMPs have the potential to represent candidate, early non-invasive biomarkers for diagnosis and/or response to therapy. In addition, they may represent therapeutic targets for preventing chronic kidney disease progression in FSGS.
- Subjects :
- Adolescent
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Glomerulosclerosis, Focal Segmental enzymology
Humans
Male
Nephrotic Syndrome urine
Pilot Projects
Biomarkers urine
Glomerulosclerosis, Focal Segmental urine
Matrix Metalloproteinase 2 urine
Matrix Metalloproteinase 9 urine
Tissue Inhibitor of Metalloproteinase-1 urine
Tissue Inhibitor of Metalloproteinase-2 urine
Subjects
Details
- Language :
- English
- ISSN :
- 1432-198X
- Volume :
- 26
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 21720805
- Full Text :
- https://doi.org/10.1007/s00467-011-1897-7