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High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study.

Authors :
Santos-Silva AR
Ribeiro AC
Soubhia AM
Miyahara GI
Carlos R
Speight PM
Hunter KD
Torres-Rendon A
Vargas PA
Lopes MA
Source :
Histopathology [Histopathology] 2011 Jun; Vol. 58 (7), pp. 1127-35.
Publication Year :
2011

Abstract

Aims: This multi-centre analysis assessed the DNA content of TSCC in 37 young patients (<40 years) and 28 old patients (>50 years) and determined the correlation of DNA ploidy findings with clinicopathological data.<br />Methods and Results: Image cytometry was carried out using an automated cellular imaging system on Feulgen-stained histological sections to obtain high-fidelity DNA histograms. Among young patients, 37.8% were females compared to 18.7% in the older group (P=0.002). In total, 48.6% patients were non-smokers and 40.5% were non-drinkers compared to 10.7% non-smokers and non-drinkers in the older group (P<0.0001). TNM, clinical stage of disease and histological grade of differentiation did not differ between groups. Tumour aneuploidy was detected in 86.5% and tetraploidy in 24.3% young patients; this was significantly greater than in the older group where 64.3% were aneuploid (P<0.0001) and 7.2% tetraploid (P<0.0001). The mean values of DNA index (DI) and DNA heterogeneity index as well as the percentage of cells with DI exceeding 5N were higher in young patients (P<0.0001).<br />Conclusions: Young patients with TSCC represent a distinct clinical entity. The high incidence of DNA ploidy abnormalities suggest that they may have increased genomic instability and indicates underlying genetic differences between TSCC in young and older patients.<br /> (© 2011 Blackwell Publishing Limited.)

Details

Language :
English
ISSN :
1365-2559
Volume :
58
Issue :
7
Database :
MEDLINE
Journal :
Histopathology
Publication Type :
Academic Journal
Accession number :
21707713
Full Text :
https://doi.org/10.1111/j.1365-2559.2011.03863.x