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The impact of caspase-12 on susceptibility to candidemia.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2012 Mar; Vol. 31 (3), pp. 277-80. Date of Electronic Publication: 2011 Jun 25. - Publication Year :
- 2012
-
Abstract
- Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a susceptibility factor for bacterial sepsis. In populations of African descent, CASPASE-12 is either functional or non-functional. Here, we have assessed the frequencies of both CASPASE-12 alleles in an African-American Candida sepsis patients cohort compared to uninfected patients with similar predisposing factors. African-American Candida sepsis patients (n = 93) and non-infected African-American patients (n = 88) were genotyped for the CASPASE-12 genotype. Serum cytokine concentrations of IL-6, IL-8, and IFNγ were measured in the serum of infected patients. Statistical comparisons were performed in order to assess the effect of the CASPASE-12 genotype on susceptibility to candidemia and on serum cytokine concentrations. Our findings demonstrate that CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients.
- Subjects :
- Candida pathogenicity
Disease Susceptibility
Female
Genetic Variation
Genotype
Humans
Interferon-gamma genetics
Interleukin-6 genetics
Interleukin-8 genetics
Male
Middle Aged
Sepsis blood
Sepsis genetics
Black or African American genetics
Candidemia genetics
Caspase 12 genetics
Interferon-gamma blood
Interleukin-6 blood
Interleukin-8 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 21706251
- Full Text :
- https://doi.org/10.1007/s10096-011-1307-x