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Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor.

Authors :
Monnard FW
Heinisch T
Nogueira ES
Schirmer T
Ward TR
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Aug 07; Vol. 47 (29), pp. 8238-40. Date of Electronic Publication: 2011 Jun 27.
Publication Year :
2011

Abstract

d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 Å resolution X-ray crystal structure of [(η(6)-C(6)Me(6))Ru(bispy 3)Cl](+)⊂ hCA II highlights the nature of the host-guest interactions.

Details

Language :
English
ISSN :
1364-548X
Volume :
47
Issue :
29
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
21706094
Full Text :
https://doi.org/10.1039/c1cc10345h