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Limbic response to psychosocial stress in schizotypy: a functional magnetic resonance imaging study.
- Source :
-
Schizophrenia research [Schizophr Res] 2011 Sep; Vol. 131 (1-3), pp. 184-91. Date of Electronic Publication: 2011 Jun 25. - Publication Year :
- 2011
-
Abstract
- Psychological stress causes dopamine release in the striatum and is thought to play a role in susceptibility to psychotic illness. Previous work suggests that an elevated dopaminergic response to stress may index vulnerability to psychosis in certain individuals. With functional magnetic resonance imaging, we measured stress-induced changes in brain activity in healthy individuals at elevated risk of developing psychosis. Participants were 15 controls and 25 psychometric schizotypes: 12 with positive symptom schizotypy (perceptual aberrations) and 13 with negative symptom schizotypy (physical anhedonia), as determined by questionnaires (Chapman et al., 1976; Chapman and Chapman, 1978). In the scanner, participants performed the Montreal Imaging Stress Task and a matched sensory-motor control task. Measures of self-reported stress and salivary cortisol levels were taken throughout the experiment. All three groups showed significant increases in self-reported stress and significant fMRI signal change in the striatal, limbic and cortical regions. However, the Physical Anhedonia group showed greater stress-induced striatal and limbic deactivation than the other two groups. Deactivation in the striatum was significantly correlated with Physical Anhedonia score across all subjects. Our findings suggest the presence of abnormalities in striatal response to stress in negative symptom schizotypy.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Brain Mapping
Female
Humans
Hydrocortisone metabolism
Image Processing, Computer-Assisted
Linear Models
Male
Oxygen blood
Personality Inventory
Psychiatric Status Rating Scales
Saliva
Schizotypal Personality Disorder complications
Stress, Psychological complications
Young Adult
Limbic System blood supply
Magnetic Resonance Imaging
Schizotypal Personality Disorder pathology
Stress, Psychological pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2509
- Volume :
- 131
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 21705195
- Full Text :
- https://doi.org/10.1016/j.schres.2011.05.016