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Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease.
- Source :
-
Neurology [Neurology] 2011 Jul 05; Vol. 77 (1), pp. 48-54. Date of Electronic Publication: 2011 Jun 22. - Publication Year :
- 2011
-
Abstract
- Objectives: Incidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI. MH have been linked with β-amyloid (Aβ) deposition using (11)C-Pittsburgh compound B (PiB) PET in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA). We hypothesized that Aβ deposition in asymptomatic elderly individuals is associated with lobar MH (LMH).<br />Methods: This was a cross-sectional study of 84 elderly healthy controls (HC), 28 subjects with mild cognitive impairment (MCI), and 26 subjects with probable AD who underwent 3-T SWI and (11)C-PiB PET. (11)C-PiB cortical binding was quantified normalized to cerebellar cortex (standardized uptake value ratio [SUVR]) and scans classified as positive (PiB+) or negative (PiB-) by visual inspection. MH were manually counted and categorized by region and as lobar or nonlobar.<br />Results: LMH were present in 30.8% of AD, 35.7% of MCI, and 19.1% of HC. The prevalence of LMH among PiB+ subjects was similar, regardless of clinical classification (AD 30.8%, MCI 38.9%, HC 41.4%, p > 0.7). HC with LMH had significantly higher mean neocortical SUVR (1.7 ± 0.5) than HC without LMH (1.3 ± 0.3, p ± 0.01). In HC, there was a positive correlation between number of LMH and SUVR, and between LMH and age. In HC, PiB+ (odds ratio [OR] 7.3, 95% confidence interval [CI] 1.6-33.7, p = 0.01) and age (OR 1.2, 95% CI 1.03-1.3, p = 0.02) both independently predicted the occurrence of LMH using logistic regression.<br />Conclusion: Asymptomatic Aβ deposition in older adults is strongly associated with LMH.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease diagnostic imaging
Alzheimer Disease genetics
Aniline Compounds
Apolipoprotein E4 genetics
Benzothiazoles
Brain diagnostic imaging
Brain Mapping
Carbon Radioisotopes
Cognition Disorders diagnostic imaging
Cognition Disorders genetics
Cognition Disorders pathology
Female
Humans
Logistic Models
Magnetic Resonance Imaging methods
Male
Nerve Fibers, Myelinated diagnostic imaging
Nerve Fibers, Myelinated pathology
Positron-Emission Tomography methods
Psychiatric Status Rating Scales
Thiazoles
Aging pathology
Alzheimer Disease pathology
Amyloid beta-Peptides metabolism
Brain metabolism
Cerebral Hemorrhage etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 77
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 21700585
- Full Text :
- https://doi.org/10.1212/WNL.0b013e318221ad36