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Oncologic outcomes in advanced laryngeal squamous cell carcinomas treated with different modalities in a single institution: a retrospective analysis of 65 cases.
- Source :
-
Head & neck [Head Neck] 2012 Apr; Vol. 34 (4), pp. 573-9. Date of Electronic Publication: 2011 Jun 20. - Publication Year :
- 2012
-
Abstract
- Background: Treatment for laryngeal squamous cell carcinoma (SCC) has been predominantly surgical for decades, but in the last 20 years nonsurgical modalities (radiotherapy), with the aim of organ preservation, also became predominant among advanced stages. Retrospectively evaluating our series of stage III and stage IV laryngeal SCCs, we compared the 2 main therapeutic modalities.<br />Methods: Medical records of 65 consecutive patients with advanced laryngeal SCC, from November 2005 to January 2009, were reviewed.<br />Results: Among irradiated patients 2-year organ preservation was 86% for cT2, 43% for cT3, and 17% for cT4a (p = .037, Wilcoxon test). With respect to survival, the only significant differences between surgery and radiotherapy were detected among cT4a SCCs (p = .03, Wilcoxon test), in favor of surgery.<br />Conclusions: The present results confirm the surgical recommendation for cT4a laryngeal SCCs. On the other hand, for T < 4, our results confirm that radiochemotherapy warrants a survival similar to that of total laryngectomy, thus allowing us to preserve the larynx in a relevant number of cases.<br /> (Copyright © 2011 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Cohort Studies
Disease-Free Survival
Female
Follow-Up Studies
Humans
Italy
Laryngeal Neoplasms pathology
Laryngectomy mortality
Male
Middle Aged
Neoplasm Invasiveness pathology
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Radiotherapy Dosage
Radiotherapy, Adjuvant
Retrospective Studies
Risk Assessment
Statistics, Nonparametric
Survival Analysis
Time Factors
Treatment Outcome
Carcinoma, Squamous Cell mortality
Chemoradiotherapy methods
Laryngeal Neoplasms mortality
Laryngeal Neoplasms therapy
Laryngectomy methods
Neoplasm Recurrence, Local therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 21692130
- Full Text :
- https://doi.org/10.1002/hed.21785