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Pancreatic endocrine tumors with major vascular abutment, involvement, or encasement and indication for resection.
- Source :
-
Archives of surgery (Chicago, Ill. : 1960) [Arch Surg] 2011 Jun; Vol. 146 (6), pp. 724-32. - Publication Year :
- 2011
-
Abstract
- Background: Surgery for pancreatic endocrine tumors (PETs) with blood vessel involvement is controversial.<br />Hypothesis: Resection of PETs with major blood vessel involvement can be beneficial.<br />Design: The combined databases of the National Institutes of Health and Stanford University hospitals were queried.<br />Main Outcome Measures: Operation, pathologic condition, complications, and disease-free and overall survival.<br />Results: Of 273 patients with PETs, 46 (17%) had preoperative computed tomography evidence of major vascular involvement. The mean size for the primary PET was 5.0 cm. The involved major vessel was as follows: portal vein (n = 20), superior mesenteric vein or superior mesenteric artery (n = 16), inferior vena cava (n = 4), splenic vein (n = 4), and heart (n = 2). Forty-two of 46 patients had a PET removed: 12 (27%) primary only, 30 (68%) with lymph nodes, and 18 (41%) with liver metastases. PETs were removed by either enucleation (n = 7) or resection (n = 35). Resections included distal or subtotal pancreatectomy in 23, Whipple in 10, and total in 2. Eighteen patients had concomitant liver resection: 10 wedge resection and 8 anatomic resections. Nine patients had vascular reconstruction: each had reconstruction of the superior mesenteric vein and portal vein, and 1 had concomitant reconstruction of the superior mesenteric artery. There were no deaths, but 12 patients had complications. Eighteen patients (41%) were immediately disease free, and 5 recurred with follow-up, leaving 13 (30%) disease-free long term. The 10-year overall survival was 60%. Functional tumors were associated with a better overall survival (P < .001), and liver metastases decreased overall survival (P < .001).<br />Conclusion: These findings suggest that surgical resection of PETs with vascular abutment/invasion and nodal or distant metastases is indicated.
- Subjects :
- Adult
Aged
Female
Gastrinoma blood supply
Gastrinoma diagnostic imaging
Gastrinoma pathology
Gastrinoma surgery
Glucagonoma blood supply
Glucagonoma diagnostic imaging
Glucagonoma pathology
Glucagonoma surgery
Humans
Male
Middle Aged
Multiple Endocrine Neoplasia Type 1 blood supply
Multiple Endocrine Neoplasia Type 1 pathology
Multiple Endocrine Neoplasia Type 1 surgery
Neoplasm Invasiveness
Pancreatic Neoplasms blood supply
Pancreatic Neoplasms diagnostic imaging
Tomography, X-Ray Computed
Young Adult
Pancreatic Neoplasms pathology
Pancreatic Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1538-3644
- Volume :
- 146
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of surgery (Chicago, Ill. : 1960)
- Publication Type :
- Academic Journal
- Accession number :
- 21690450
- Full Text :
- https://doi.org/10.1001/archsurg.2011.129