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An instructive role for patterned spontaneous retinal activity in mouse visual map development.
- Source :
-
Neuron [Neuron] 2011 Jun 23; Vol. 70 (6), pp. 1115-27. - Publication Year :
- 2011
-
Abstract
- Complex neural circuits in the mammalian brain develop through a combination of genetic instruction and activity-dependent refinement. The relative role of these factors and the form of neuronal activity responsible for circuit development is a matter of significant debate. In the mammalian visual system, retinal ganglion cell projections to the brain are mapped with respect to retinotopic location and eye of origin. We manipulated the pattern of spontaneous retinal waves present during development without changing overall activity levels through the transgenic expression of β2-nicotinic acetylcholine receptors in retinal ganglion cells of mice. We used this manipulation to demonstrate that spontaneous retinal activity is not just permissive, but instructive in the emergence of eye-specific segregation and retinotopic refinement in the mouse visual system. This suggests that specific patterns of spontaneous activity throughout the developing brain are essential in the emergence of specific and distinct patterns of neuronal connectivity.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Action Potentials
Animals
Brain Mapping
Gene Expression Regulation
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Models, Neurological
Neurons cytology
Neurons physiology
Receptors, Nicotinic genetics
Retina cytology
Retina growth & development
Visual Cortex cytology
Visual Cortex metabolism
Visual Pathways cytology
Visual Pathways metabolism
Receptors, Nicotinic metabolism
Retina metabolism
Retinal Ganglion Cells metabolism
Visual Cortex growth & development
Visual Pathways growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 70
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 21689598
- Full Text :
- https://doi.org/10.1016/j.neuron.2011.04.028