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Regional brain c-fos activation associated with penile erection and other symptoms induced by the spider toxin Tx2-6.
- Source :
-
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2011 Aug; Vol. 58 (2), pp. 202-8. Date of Electronic Publication: 2011 Jun 12. - Publication Year :
- 2011
-
Abstract
- Brain areas expressing c-fos messenger RNA were mapped by quantitative in situ hybridization after 1-2 h of intoxication with 10 μg/kg Tx2-6, a toxin obtained from the venom of the spider Phoneutria nigriventer. Relative to saline-treated controls, brains from toxin-treated animals showed pronounced c-fos activation in many brain areas, including the supraoptic nucleus, the paraventricular nucleus of the hypothalamus, the motor nucleus of the vagus, area postrema, paraventricular and paratenial nuclei of the thalamus, locus coeruleus, central amydaloid nucleus and the bed nucleus of the stria terminalis. The paraventricular hypothalamus and the bed nucleus of the stria terminalis have been implicated in erectile function in other studies. A possible role for central NO is considered. Acute stress also activates many brain areas activated by Tx2-6 as well as with NOstimulated Fos transcription. Brain areas that appear to be selectively activated by Tx2-6, include the paratenial and paraventricular thalamic nuclei, the bed nucleus of the stria terminalis and the area postrema and the dorsal motor n. of vagus in the medulla. However, direct injections of different doses of the toxin into the paraventricular hypothalamic n. failed to induce penile erection, arguing against CNS involvement in this particular effect.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Arthropod Proteins administration & dosage
Arthropod Proteins chemistry
Arthropod Proteins toxicity
Biomarkers metabolism
Brain metabolism
Brain pathology
Central Nervous System Agents administration & dosage
Central Nervous System Agents toxicity
Dose-Response Relationship, Drug
In Situ Hybridization
Injections, Intraventricular
Male
Mice
Nerve Tissue Proteins agonists
Nerve Tissue Proteins genetics
Neurons metabolism
Neurons pathology
Neurotoxins administration & dosage
Neurotoxins chemistry
Organ Specificity
Peptides administration & dosage
Peptides chemistry
Proto-Oncogene Proteins c-fos agonists
Proto-Oncogene Proteins c-fos genetics
RNA, Messenger metabolism
Sodium Channel Agonists
Spider Bites metabolism
Spider Bites pathology
Spider Venoms administration & dosage
Spider Venoms chemistry
Brain drug effects
Nerve Tissue Proteins metabolism
Neurons drug effects
Neurotoxins toxicity
Penile Erection drug effects
Peptides toxicity
Proto-Oncogene Proteins c-fos metabolism
Spider Venoms toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3150
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Publication Type :
- Academic Journal
- Accession number :
- 21684302
- Full Text :
- https://doi.org/10.1016/j.toxicon.2011.05.019