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Protein nitrotryptophan: formation, significance and identification.
- Source :
-
Journal of proteomics [J Proteomics] 2011 Oct 19; Vol. 74 (11), pp. 2300-12. Date of Electronic Publication: 2011 Jun 06. - Publication Year :
- 2011
-
Abstract
- Reactive nitrogen species are formed during a variety of disease states and have been shown to modify several amino acids on proteins. To date, the majority of research in this area has focused on the nitration of tyrosine residues to form 3-nitrotyrosine. However, emerging evidence suggests that another modification, nitration of tryptophan residues, to form nitrotryptophan (NO(2)-Trp), may also play a significant role in the biology of nitrosative stress. This review takes an in-depth look at NO(2)-Trp, presenting the current research about its formation, prevalence and biological significance, as well as the methods used to identify NO(2)-Trp-modified proteins. Although more research is needed to understand the full biological role of NO(2)-Trp, the data presented herein suggest a contribution to nitrosative stress-induced cell dysregulation and perhaps even in physiological cell processes.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Bacteria drug effects
Bacteria metabolism
Humans
Models, Biological
Nitro Compounds pharmacology
Nitrosation physiology
Protein Processing, Post-Translational
Proteins physiology
Nitro Compounds isolation & purification
Nitro Compounds metabolism
Proteins isolation & purification
Proteins metabolism
Reactive Nitrogen Species metabolism
Tryptophan metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1876-7737
- Volume :
- 74
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of proteomics
- Publication Type :
- Academic Journal
- Accession number :
- 21679780
- Full Text :
- https://doi.org/10.1016/j.jprot.2011.05.032