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The effects of bradykinin and the ischemic isolated rat heart.
- Source :
-
Hormone and metabolic research. Supplement series [Horm Metab Res Suppl] 1990; Vol. 22, pp. 85-9. - Publication Year :
- 1990
-
Abstract
- The converting enzyme not only converts angiotensin I into angiotensin II but also metabolizes bradykinin. Furthermore, the effects of ischemia on myocardial tissue damage can be modulated by converting enzyme inhibitors. It is unknown whether these effects of ACE-inhibitors are due to increased bradykinin production. In this paper we describe the effects of captopril on bradykinin production in the ischemic isolated rat heart. The reduced deleterious effects of ischemia by captopril were associated with a stimulated bradykinin production. Beneficial effects of bradykinin could be due to an improved perfusion or to an effect on cellular metabolism. Therefore, we conclude that this effect on kinins by ACE-inhibitors is of importance in modulating tissue damage during ischemia.
- Subjects :
- Animals
Bradykinin antagonists & inhibitors
Bradykinin biosynthesis
Captopril analogs & derivatives
Captopril pharmacology
Coronary Circulation drug effects
Coronary Vessels drug effects
Enalaprilat pharmacology
Indomethacin pharmacology
Rats
Vasodilation drug effects
Angiotensin-Converting Enzyme Inhibitors pharmacology
Bradykinin pharmacology
Coronary Disease metabolism
Myocardium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0170-5903
- Volume :
- 22
- Database :
- MEDLINE
- Journal :
- Hormone and metabolic research. Supplement series
- Publication Type :
- Academic Journal
- Accession number :
- 2167866