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[Interest of blood markers in predicting radiation-induced toxicity].
- Source :
-
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2011 Aug; Vol. 15 (5), pp. 390-3. Date of Electronic Publication: 2011 Jun 14. - Publication Year :
- 2011
-
Abstract
- The oncologic outcome and the total dose are highly correlated with the treatment by ionizing radiation. The dose increase (total or per fraction) may provoke late-side effects that are potentially irreversible. The radiation-induced CD8 lymphocyte apoptotic value and the molecular modifications within the lymphocyte are capable of predicting the level of risk of developing late-side effects after curative intent radiotherapy. In this review, we present the different blood assays in this setting and discuss the current possibilities of researches, namely those involving the proteomic process.<br /> (Copyright © 2011 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.)
- Subjects :
- Apoptosis radiation effects
CD8-Positive T-Lymphocytes radiation effects
Cells, Cultured radiation effects
Colony-Forming Units Assay
Databases, Factual
Fibroblasts radiation effects
Flow Cytometry
Gene Expression Regulation, Neoplastic radiation effects
Humans
Lymphocyte Count
Neoplasm Proteins biosynthesis
Neoplasm Proteins genetics
Organs at Risk
Prospective Studies
Radiotherapy Dosage
Biomarkers blood
Neoplasm Proteins blood
Proteomics methods
Radiation Injuries prevention & control
Radiation Tolerance
Radiotherapy adverse effects
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6658
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
- Publication Type :
- Academic Journal
- Accession number :
- 21676639
- Full Text :
- https://doi.org/10.1016/j.canrad.2011.02.006