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Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2011 Aug 15; Vol. 174 (4), pp. 459-67. Date of Electronic Publication: 2011 Jun 14. - Publication Year :
- 2011
-
Abstract
- Aspirin use decreases colon cancer risk, but this association may vary among population subgroups. The aspirin-colon cancer association was evaluated according to body mass index and physical activity in 1,701 incident colon cancer cases diagnosed during follow-up of 139,310 participants for up to 26 years in 2 US prospective cohort studies that began in 1980 and 1992, respectively. Whether plasma C-peptide levels modified the association was examined by using a nested case-control design (n = 384 cases, 749 controls). Multiplicative and additive interactions were tested. Body mass index did not modify the association; pooled multivariable relative risks for regular aspirin use versus nonuse ranged from 0.74 to 0.75 in the normal weight and obese groups (test for multiplicative interaction, P = 0.75; test for additive interaction, P = 0.66). Pooled multivariable relative risks for regular aspirin use were 0.86 (95% confidence interval (CI): 0.66, 1.11) in the low and 0.67 (95% CI: 0.58, 0.77) in the high physical activity groups with no interaction evident on either the multiplicative or additive scale (P > 0.10). Plasma C-peptide levels also did not modify the aspirin-colon cancer association, with multivariable relative risks of 0.74 (95% CI: 0.50, 1.10) for the low and 0.65 (95% CI: 0.46, 0.92) for the high group. Reductions in colon cancer risk associated with aspirin use were not significantly modified by body mass index, physical activity, or plasma C-peptide level in this study.
- Subjects :
- Adult
Aged
Case-Control Studies
Chi-Square Distribution
Colonic Neoplasms blood
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk
Surveys and Questionnaires
United States epidemiology
Aspirin administration & dosage
Body Mass Index
C-Peptide blood
Colonic Neoplasms epidemiology
Health Personnel
Motor Activity
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 174
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 21673123
- Full Text :
- https://doi.org/10.1093/aje/kwr115