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Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2011 Jul 28; Vol. 54 (14), pp. 5245-9. Date of Electronic Publication: 2011 Jun 28. - Publication Year :
- 2011
-
Abstract
- Transition metal complexes bearing amino linked N-heterocyclic carbenes (NHC) were prepared and evaluated for their antiproliferative activities in human cancer cells. The optimum antiproliferative activity, observed for the gold complex 3 in U-87 MG cells, was found to involve S-phase arrest of the cell cycle. The results indicate that 3 induces apoptosis through a p53-bak pathway, a finding that could serve as a new strategy to reduce the resistance of cancer cells to p53-induced apoptosis.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Coordination Complexes chemistry
Coordination Complexes pharmacology
Cyclin A biosynthesis
Cyclin B biosynthesis
Cyclin-Dependent Kinase 2 biosynthesis
Drug Screening Assays, Antitumor
Humans
Imidazoles chemistry
Imidazoles pharmacology
Methane chemical synthesis
Methane chemistry
Methane pharmacology
S Phase
Structure-Activity Relationship
Tumor Suppressor Protein p53 physiology
bcl-2 Homologous Antagonist-Killer Protein physiology
Antineoplastic Agents chemical synthesis
Apoptosis
Coordination Complexes chemical synthesis
Gold
Imidazoles chemical synthesis
Methane analogs & derivatives
Palladium
Silver
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4804
- Volume :
- 54
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21671598
- Full Text :
- https://doi.org/10.1021/jm101096x