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Beneficial influence of postmenopausal estrogen therapy on serum adhesion molecules is independent of the route and dose of administration.
- Source :
-
Neuro endocrinology letters [Neuro Endocrinol Lett] 2011; Vol. 32 (3), pp. 340-4. - Publication Year :
- 2011
-
Abstract
- Objective: In current literature, the immune-inflammatory theory of atherosclerosis is widely discussed. The role of how adhesion molecules contribute to the development of atheromatic plaques is especially underlined.<br />Material and Methods: 120 females in menopausal age were included in the study between 2004 and 2009. All the women were of menopausal age (51±3 years), from southern Poland, with FSH levels above 30 mIU/ml, and complaining of menopausal symptoms that disturbed normal daily activity. The study was conducted over a 6 month period. Three groups of 40 randomized patients were selected. The control group consisted of 40 volunteers, who were also from southern Poland, in good health, without menopausal symptoms, or menstrual periods in the last 6 months. Control subjects were match according to age and weight, with FSH levels above 25 mIU/ml and normal TSH and prolactin values. All patients, in the treatment and control groups were seronegative for Chlamydia pneumonia throughout the duration of the study.<br />Results: After 6 months, hormonal therapy was found to significantly reduce levels of sICAM-1 and sVCAM-1 in all treated groups compared to the control group and the results were statistically significant. Alternatively, in the latter group, we observed increased levels of the investigated adhesion molecules (group I: 37.5 µg/24h transdermal estradiol + dydrogesteron; group II 50 µg/24h transdermal estradiol + medroxyprogesteron; group III 1mg of oral estradiol + noretisteron sICAM-1 and control group; using paired Wilcoxon test).<br />Conclusion: All of the investigated estrogen therapy schemas have a favorable impact on the blood levels of sICAM-1 and sVCAM-1 in postmenopausal women without cardiovascular risk factors, reducing their concentration.
- Subjects :
- Administration, Cutaneous
Cholesterol blood
Climacteric
Dose-Response Relationship, Drug
Dydrogesterone administration & dosage
Dydrogesterone therapeutic use
Endothelial Cells drug effects
Estradiol administration & dosage
Estradiol therapeutic use
Female
Hormones blood
Humans
Intercellular Adhesion Molecule-1 blood
Lipoproteins blood
Medroxyprogesterone administration & dosage
Medroxyprogesterone therapeutic use
Middle Aged
Poland
Progestins administration & dosage
Progestins therapeutic use
Vascular Cell Adhesion Molecule-1 blood
Cell Adhesion Molecules blood
Estrogen Replacement Therapy
Estrogens administration & dosage
Estrogens therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0172-780X
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuro endocrinology letters
- Publication Type :
- Academic Journal
- Accession number :
- 21670727