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Polytherapy in bone regeneration: clinical applications and preliminary considerations.
- Source :
-
International journal of immunopathology and pharmacology [Int J Immunopathol Pharmacol] 2011 Jan-Mar; Vol. 24 (1 Suppl 2), pp. 85-90. - Publication Year :
- 2011
-
Abstract
- Polytherapy, namely the simultaneous application of three fundamental elements necessary for bone regeneration (growth factors, osteogenic cells and osteoconductive scaffolds) seems to lead to a very high success rate in the treatment of complex non-union (NU) cases and critical bone defects. NU are reported in 5-10% of long bone fractures. The use of autologous bone grafts has been long-considered the gold standard for the treatment of these cases. However the harvesting procedure from the iliac crest increases surgery time and presents some donor site complications which may be elevated. In recent years, surgeons have some alternatives to autologous grafting such as: application of organic or synthetic bone substitute, application of mesenchymal stromal cells (MSC) or growth factors (GF). In the literature there are many studies available about their application in monotherapy, but unfortunately the healing rate doesn't exceed 90%. Polytherapy seems to be a logical option to improve the healing rate, nevertheless, there are not still extensive studies that validate this strategy and moreover, some questions are not resolved.
- Subjects :
- Animals
Biomarkers
Bone Diseases therapy
Bone Regeneration drug effects
Bone Substitutes
Bone Transplantation
Combined Modality Therapy
Fracture Fixation
Fractures, Bone therapy
Humans
Multicenter Studies as Topic
Up-Regulation physiology
Bone Regeneration physiology
Intercellular Signaling Peptides and Proteins therapeutic use
Osteocytes transplantation
Tissue Scaffolds
Subjects
Details
- Language :
- English
- ISSN :
- 0394-6320
- Volume :
- 24
- Issue :
- 1 Suppl 2
- Database :
- MEDLINE
- Journal :
- International journal of immunopathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21669144
- Full Text :
- https://doi.org/10.1177/03946320110241S216