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Irritable bowel syndrome and other functional gastrointestinal disorders.
- Source :
-
Journal of clinical gastroenterology [J Clin Gastroenterol] 2011 Aug; Vol. 45 Suppl, pp. S86-8. - Publication Year :
- 2011
-
Abstract
- Irritable bowel syndrome is one of several highly prevalent functional gastrointestinal disorders (FGID) displaying symptoms of gastrointestinal dysmotility and visceral hypersensitivity. Substantial overlap of symptoms and comorbidities occur not only between irritable bowel syndrome and other FGID but also with gastrointestinal disorders that are not related to motility (eg, celiac disease and lactose intolerance) and to somatic conditions (eg, fibromyalgia and chronic fatigue syndrome). Pathogenic mechanisms common among FGIDs may include alternations in intestinal and colonic microflora. Evidence is also emerging of an interplay between gut immune cells/activity and alternations in motility, secretion, and sensation. The role of cytokine activity and inflammation is important in this regard. As recommended by Rome III, diagnostic testing should be guided by the patient's age, primary symptom characteristics, and other clinical and laboratory features. The high prevalence of coexisting conditions suggests the need to routinely assess patients for related disorders. Treatment should be based on an individualized evaluation, explanation, and reassurance.
- Subjects :
- Celiac Disease diagnosis
Celiac Disease epidemiology
Celiac Disease physiopathology
Comorbidity
Esophageal Diseases diagnosis
Esophageal Diseases epidemiology
Esophageal Diseases physiopathology
Fatigue Syndrome, Chronic diagnosis
Fatigue Syndrome, Chronic epidemiology
Fatigue Syndrome, Chronic physiopathology
Fibromyalgia diagnosis
Fibromyalgia epidemiology
Fibromyalgia physiopathology
Humans
Lactose Intolerance epidemiology
Lactose Intolerance physiopathology
Prevalence
Gastrointestinal Diseases diagnosis
Gastrointestinal Diseases epidemiology
Gastrointestinal Diseases physiopathology
Irritable Bowel Syndrome diagnosis
Irritable Bowel Syndrome epidemiology
Irritable Bowel Syndrome physiopathology
Lactose Intolerance diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2031
- Volume :
- 45 Suppl
- Database :
- MEDLINE
- Journal :
- Journal of clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 21666425
- Full Text :
- https://doi.org/10.1097/MCG.0b013e31821fbd6f