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Correlation between metabolic tumor volume and pathologic tumor volume in squamous cell carcinoma of the oral cavity.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2011 Dec; Vol. 101 (3), pp. 356-61. Date of Electronic Publication: 2011 Jun 12. - Publication Year :
- 2011
-
Abstract
- Purpose: To explore the relationship between pathologic tumor volume and volume estimated from different tumor segmentation techniques on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in oral cavity cancer.<br />Materials and Methods: Twenty-three patients with squamous cell carcinoma of the oral tongue had PET-CT scans before definitive surgery. Pathologic tumor volume was estimated from surgical specimens. Metabolic tumor volume (MTV) was defined from PET-CT scans as the volume of tumor above a given SUV threshold. Multiple SUV thresholds were explored including absolute SUV thresholds, relative SUV thresholds, and gradient-based techniques.<br />Results: Multiple MTV's were associated with pathologic tumor volume; however the correlation was poor (R(2) range 0.29-0.58). The ideal SUV threshold, defined as the SUV that generates an MTV equal to pathologic tumor volume, was independently associated with maximum SUV (p=0.0005) and tumor grade (p=0.024). MTV defined as a function of maximum SUV and tumor grade improved the prediction of pathologic tumor volume (R(2)=0.63).<br />Conclusions: Common SUV thresholds fail to predict pathologic tumor volume in head and neck cancer. The optimal technique that allows for integration of PET-CT with radiation treatment planning remains to be defined. Future investigation should incorporate biomarkers such as tumor grade into definitions of MTV.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell diagnostic imaging
Carcinoma, Squamous Cell metabolism
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoplasm Grading
Tongue Neoplasms metabolism
Carcinoma, Squamous Cell pathology
Multimodal Imaging methods
Positron-Emission Tomography
Tomography, X-Ray Computed
Tongue Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 101
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21665308
- Full Text :
- https://doi.org/10.1016/j.radonc.2011.05.040