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Mini Mental State Examination over time in chronic hemodialysis patients.
- Source :
-
Journal of psychosomatic research [J Psychosom Res] 2011 Jul; Vol. 71 (1), pp. 50-4. Date of Electronic Publication: 2011 Mar 01. - Publication Year :
- 2011
-
Abstract
- Objective: Cognitive impairment is relatively common in end-stage renal disease patients on chronic hemodialysis, but the course of cognitive function deterioration in hemodialysis patients is essentially unknown. The present study aimed to evaluate if changes in Mini Mental State Examination (MMSE) over time in hemodialysis (HDP) and elderly (EP) patients differ significantly and determine the variables associated with such possible changes.<br />Methods: In 80 HDP and 160 EP, the MMSE was assessed at baseline and after 1 year. Patients were stratified at baseline and at 1 year into three groups according to the MMSE: normal cognitive function >23; mild-moderate cognitive dysfunction: 18-23; severe cognitive dysfunction: <18. Univariate and multivariate analyses were performed to determine the variables associated with MMSE change over time<br />Results: One-year median reduction of MMSE was greater in HDP (from 24 to 21) than in EP (from 26 to 25) (P<.0001). A higher percentage of HDP than EP switched from normal to mild-moderate or severe MMSE group (P<.0001). At baseline, MMSE was negatively correlated with hypertension (P=.013), angina (P=.007) and Beck Depression Inventory (P=.041) and positively correlated with education (P=.017) and male gender (P=.015). No factors were found to be significantly associated with change of MMSE between baseline and month 12 in HDP.<br />Conclusion: One-year MMSE reduction was greater in HDP that in EP. No factors were associated with MMSE reduction in HDP. However, it remains likely that cardiovascular comorbidities and low haemoglobin levels are related to such decline.<br /> (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Cognition
Cognition Disorders complications
Cognition Disorders psychology
Female
Humans
Kidney Failure, Chronic complications
Kidney Failure, Chronic therapy
Male
Mental Status Schedule
Middle Aged
Neuropsychological Tests
Aging psychology
Cognition Disorders diagnosis
Kidney Failure, Chronic psychology
Renal Dialysis psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1360
- Volume :
- 71
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of psychosomatic research
- Publication Type :
- Academic Journal
- Accession number :
- 21665013
- Full Text :
- https://doi.org/10.1016/j.jpsychores.2011.01.001