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Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2011 Jun 13; Vol. 10, pp. 96. Date of Electronic Publication: 2011 Jun 13. - Publication Year :
- 2011
-
Abstract
- Background: Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet.<br />Methods: The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks.<br />Results: Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably.<br />Conclusion: Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.
- Subjects :
- Animals
Antioxidants metabolism
Atherosclerosis blood
Atherosclerosis etiology
C-Reactive Protein metabolism
Catalase blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Drug Evaluation, Preclinical
Enzyme Assays
Fatty Acids, Monounsaturated
Glutathione blood
Glutathione Peroxidase blood
Interleukin-6 blood
Lipid Peroxidation drug effects
Lipids blood
Male
Phytosterols pharmacology
Polyphenols pharmacology
Rapeseed Oil
Rats
Rats, Sprague-Dawley
Risk Factors
Superoxide Dismutase blood
Thiobarbituric Acid Reactive Substances metabolism
Tocopherols pharmacology
Atherosclerosis prevention & control
Dietary Fats adverse effects
Food, Fortified
Micronutrients pharmacology
Plant Oils pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 21663699
- Full Text :
- https://doi.org/10.1186/1476-511X-10-96