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Marrow-ablative treatment and autologous stem cell transplantation in follicular NHL.
- Source :
-
Best practice & research. Clinical haematology [Best Pract Res Clin Haematol] 2011 Jun; Vol. 24 (2), pp. 257-70. Date of Electronic Publication: 2011 May 10. - Publication Year :
- 2011
-
Abstract
- High-dose therapy followed by autologous stem cell transplantation is widely accepted as salvage therapy for patients with relapsed aggressive lymphoma. In the pre-rituximab era, autologous stem cell transplantation had also been increasingly applied as a consolidation treatment for patients with indolent lymphoma in second or subsequent remission whereas controversies have emerged concerning its role in first line therapy from several randomized trials. Broad development and amazing efficacy of monoclonal antibody-based combination therapies for de novo or relapsing follicular lymphoma patients render previous conclusions outdated and underline the critical need for further phase III trials. This review focuses on available data from pre-rituximab and rituximab eras to help clarifying the precise role and timing of autologous stem cell transplantation among the current armamentarium for follicular lymphoma treatment.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antibodies, Monoclonal, Murine-Derived immunology
Bone Marrow drug effects
Bone Marrow pathology
Clinical Trials, Phase III as Topic
Humans
Lymphoma, Follicular immunology
Lymphoma, Follicular mortality
Lymphoma, Follicular pathology
Mice
Myeloablative Agonists administration & dosage
Randomized Controlled Trials as Topic
Recurrence
Remission Induction
Rituximab
Survival Rate
Transplantation, Autologous
Antibodies, Monoclonal, Murine-Derived therapeutic use
Hematopoietic Stem Cell Transplantation
Immunoconjugates therapeutic use
Immunotherapy methods
Lymphoma, Follicular therapy
Salvage Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1924
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Best practice & research. Clinical haematology
- Publication Type :
- Academic Journal
- Accession number :
- 21658622
- Full Text :
- https://doi.org/10.1016/j.beha.2011.03.001