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Cognitive-behavioral therapy for sleep disturbance decreases inflammatory cytokines and oxidative stress in hemodialysis patients.
- Source :
-
Kidney international [Kidney Int] 2011 Aug; Vol. 80 (4), pp. 415-22. Date of Electronic Publication: 2011 Jun 08. - Publication Year :
- 2011
-
Abstract
- Sleep disturbance is common in dialysis patients and is associated with the development of enhanced inflammatory responses. Cognitive-behavioral therapy is effective for sleep disturbance and reduces inflammation experienced by peritoneal dialysis patients; however, this has not been studied in hemodialysis patients. To determine whether alleviation of sleep disturbance in hemodialysis patients also leads to less inflammation, we conducted a randomized controlled interventional study of 72 sleep-disturbed hemodialysis patients. Within this patient cohort, 37 received tri-weekly cognitive-behavioral therapy lasting 6 weeks and the remaining 35, who received sleep hygiene education, served as controls. The adjusted post-trial primary outcome scores of the Pittsburgh Sleep Quality Index, the Fatigue Severity Scale, the Beck Depression Inventory, and the Beck Anxiety Inventory were all significantly improved from baseline by therapy compared with the control group. The post-trial secondary outcomes of high-sensitive C-reactive protein, IL-18, and oxidized low-density lipoprotein levels significantly declined with cognitive-behavioral therapy in comparison with the control group. Thus, our results suggest that cognitive-behavioral therapy is effective for correcting disorganized sleep patterns, and for reducing inflammation and oxidative stress in hemodialysis patients.
- Subjects :
- Aged
Analysis of Variance
Biomarkers blood
Down-Regulation
Female
Humans
Inflammation etiology
Inflammation immunology
Inflammation metabolism
Inflammation psychology
Male
Middle Aged
Prospective Studies
Sleep Wake Disorders etiology
Sleep Wake Disorders immunology
Sleep Wake Disorders metabolism
Sleep Wake Disorders physiopathology
Sleep Wake Disorders psychology
Surveys and Questionnaires
Taiwan
Time Factors
Treatment Outcome
Cognitive Behavioral Therapy
Cytokines blood
Inflammation therapy
Inflammation Mediators blood
Oxidative Stress
Renal Dialysis adverse effects
Sleep
Sleep Wake Disorders therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 80
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 21654719
- Full Text :
- https://doi.org/10.1038/ki.2011.151