Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts.

Authors :: Morita H
Zaima K
Koga I
Saito A
Tamamoto H
Okazaki H
Kaneda T
Hashimoto T
Asakawa Y
Source :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2011 Jul 01; Vol. 19 (13), pp. 4051-6. Date of Electronic Publication: 2011 May 19.
Publication Year :: 2011
Abstract: Vasorelaxant effects of a series of bis(bibenzyls) from liverworts such as Marchantia polymorpha and Marchantia paleacea on rat aorta demonstrated that they relaxed phenylephrine (PE)-induced contractions, which may be mediated through the increased release of NO from endothelial cells as well as opening of K(+) channels, and inhibition of Ca(2+) influx through voltage-dependent Ca(2+) channels (VDCs) and/or receptor-operated Ca(2+) channels (ROCs). Structure-activity relationship based on their structures was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer may play an important role for vasorelaxant effect.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)