HLA-DRB1/DQB1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia.

Authors :: Fourati H
Mahfoudh N
Abida O
Kammoun A
Mnif F
Haddouk S
Ben Ayed M
Ben Hadj Hmida Y
Rekik N
Abid M
Makni H
Masmoudi H
Source :: Annales d'endocrinologie [Ann Endocrinol (Paris)] 2011 Jun; Vol. 72 (3), pp. 232-8. Date of Electronic Publication: 2011 Jun 08.
Publication Year :: 2011
Abstract: Objectives: The aim of our study was to investigate the association of HLA-DRB1 and HLA-DQB1 alleles with autoimmune polyglandular syndromes (APS) type II and III in a southern Tunisian population.<br />Patients and Methods: Sixty-two unrelated patients with APSII (n=20) and APSIII (n=42) and 146 healthy controls were genotyped for HLA class II alleles (DRB1*, DQB1*) by PCR-SSP technique.<br />Results: An increased frequencies of HLA-DQB1*03:02 (P=0,02; OR=2.98) in APSII patients, HLA-DRB1*03 (P=310(-6); OR=4.28) and HLA-DQB1*02:01 (P=0.04; OR=1.95) in APSIII patients were found compared to healthy controls. Study of the HLA-DRB1*;DQB1* haplotype frequencies showed a higher occurrence of DRB1*04;DQB1*03:02 and DRB1*03;DQB1*02:01 in APSII patients (P=410(-3); OR=3.31 and P=0.03; OR=2.74 respectively) whereas APSIII was only associated with DRB1*03;DQB1*02:01 (P=7.210(-8), OR=4.71).<br />Conclusion: Our data suggest that the variation in class II HLA alleles and haplotypes could be a genetic factor involved in the susceptibility of APS syndrome.<br /> (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)

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