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Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice.
- Source :
-
Cancer investigation [Cancer Invest] 2011 Jul; Vol. 29 (6), pp. 396-404. - Publication Year :
- 2011
-
Abstract
- APC(min/+) mice, carrying a nonsense mutation in the adenomatous polyposis coli (APC) gene, appear as a perfect model to study development or therapy of intestinal neoplasia. We tested whether the flavonoid flavone is able to affect adenoma development in APC(min/+) mice. Tumor sizes were significantly increased by flavone selectively in small intestine. This was associated with reduced cell numbers displaying cleaved caspase-3 and enhanced expression of phosphoglycoprotein (P-gp). However, according to great variability in P-gp expression in all parts of mice intestines, an association between expression of P-gp and inhibition of apoptosis was demonstrated in human Caco-2 colorectal cancer cells.
- Subjects :
- Adenomatous Polyposis Coli Protein genetics
Adenomatous Polyposis Coli Protein metabolism
Animals
Caco-2 Cells
Female
Humans
Ileum drug effects
Ileum pathology
Jejunum drug effects
Jejunum pathology
Male
Mice
Mice, Inbred C57BL
beta Catenin physiology
ATP Binding Cassette Transporter, Subfamily B, Member 1 physiology
Adenoma pathology
Apoptosis drug effects
Flavones pharmacology
Genes, APC physiology
Intestinal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4192
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer investigation
- Publication Type :
- Academic Journal
- Accession number :
- 21649465
- Full Text :
- https://doi.org/10.3109/07357907.2011.587071