[Association of single nucleotide polymorphism in CYP17 and ERα genes with endometriosis risk in southern Chinese women].

Authors :: Zhao X
Zong LL
Wang YF
Mao T
Fu YG
Zeng J
Rao XQ
Source :: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2011 Jun; Vol. 28 (3), pp. 304-7.
Publication Year :: 2011
Abstract: Objective: To investigate the association of single nucleotide polymorphisms in cytochrome P450 17 (CYP17) and estrogen receptor alpha (ERα ) genes with the risk of endometriosis among southern Chinese women.<br />Methods: Two SNPs rs743572 (CYP17 gene 34T/C) and rs9322331 (ERα gene -397T/C) were genotyped by high resolution melting curve in 432 endometriosis patients and 499 matched controls.<br />Results: There was no significant difference in the genotype frequencies of the two loci between endometriosis patients and the control subjects (P> 0.05). And there was no significant interaction effect of these two genes on the disease either.<br />Conclusion: CYP17 gene and ERα gene may not be genetic risk factors for endometriosis among southern women in China.

Subjects :: Asian People genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Risk Factors
Endometriosis genetics
Estrogen Receptor alpha genetics
Polymorphism, Single Nucleotide
Steroid 17-alpha-Hydroxylase genetics

Language :: Chinese
ISSN :: 1003-9406
Volume :: 28
Issue :: 3
Database :: MEDLINE
Journal :: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Publication Type :: Academic Journal
Accession number :: 21644229
Full Text :: https://doi.org/10.3760/cma.j.issn.1003-9406.2011.03.015

Full Text Access

Tools