Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications.

Authors :: Mandal S
Bakeine GJ
Krol S
Ferrari C
Clerici AM
Zonta C
Cansolino L
Ballarini F
Bortolussi S
Stella S
Protti N
Bruschi P
Altieri S
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2011 Dec; Vol. 69 (12), pp. 1692-7. Date of Electronic Publication: 2011 May 18.
Publication Year :: 2011
Abstract: The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors.<br /> (Copyright Â© 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Cell Line, Tumor
Folic Acid chemistry
Humans
Microscopy, Confocal
Microscopy, Fluorescence
Boron administration & dosage
Boron analysis
Boron Neutron Capture Therapy
Gold chemistry
Metal Nanoparticles

Language :: English
ISSN :: 1872-9800
Volume :: 69
Issue :: 12
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 21641810
Full Text :: https://doi.org/10.1016/j.apradiso.2011.05.002

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