Macrolides: new therapeutic perspectives in lung diseases.

Authors :: Guillot L
Tabary O
Nathan N
Corvol H
Clement A
Source :: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2011 Sep; Vol. 43 (9), pp. 1241-6. Date of Electronic Publication: 2011 May 23.
Publication Year :: 2011
Abstract: There is strong clinical evidence for the effectiveness of macrolides in the treatment of a number of chronic airway diseases through their immunomodulatory effects. Recently, new information has been released supporting the view that macrolides may also be beneficial in pathologic situations associated with altered repair of the alveolar structure, such as those observed in interstitial lung diseases and fibrosis. It is proposed that macrolides may contribute to lung regeneration through their actions on several components of the remodeling process. The present review provides new insights on the effects of macrolides on the regenerative response of alveolar epithelium to injury. It also discusses novel findings which suggest that macrolides may contribute to alveolar surfactant homeostasis.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)