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Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance.
- Source :
-
Acta biochimica Polonica [Acta Biochim Pol] 2011; Vol. 58 (2), pp. 179-86. Date of Electronic Publication: 2011 Jun 02. - Publication Year :
- 2011
-
Abstract
- This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with high-density lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.
- Subjects :
- Adult
Blood Glucose
Blood Pressure
Body Mass Index
C-Peptide blood
Female
Haplotypes
Humans
Lipids blood
Male
Metabolic Syndrome blood
Middle Aged
Multivariate Analysis
Waist Circumference
Genetic Association Studies
Hepatocyte Nuclear Factor 4 genetics
Metabolic Syndrome genetics
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1734-154X
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta biochimica Polonica
- Publication Type :
- Academic Journal
- Accession number :
- 21633728