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Multiscale modeling of calcium dynamics in ventricular myocytes with realistic transverse tubules.
- Source :
-
IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2011 Oct; Vol. 58 (10), pp. 2947-51. Date of Electronic Publication: 2011 May 31. - Publication Year :
- 2011
-
Abstract
- Spatial-temporal Ca(2+) dynamics due to Ca(2+) release, buffering, and reuptaking plays a central role in studying excitation-contraction (E-C) coupling in both normal and diseased cardiac myocytes. In this paper, we employ two numerical methods, namely, the meshless method and the finite element method, to model such Ca(2+) behaviors by solving a nonlinear system of reaction-diffusion partial differential equations at two scales. In particular, a subcellular model containing several realistic transverse tubules (or t-tubules) is investigated and assumed to reside at different locations relative to the cell membrane. To this end, the Ca(2+) concentration calculated from the whole-cell modeling is adopted as part of the boundary constraint in the subcellular model. The preliminary simulations show that Ca(2+) concentration changes in ventricular myocytes are mainly influenced by calcium release from t-tubules.
Details
- Language :
- English
- ISSN :
- 1558-2531
- Volume :
- 58
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- IEEE transactions on bio-medical engineering
- Publication Type :
- Academic Journal
- Accession number :
- 21632291
- Full Text :
- https://doi.org/10.1109/TBME.2011.2158316