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Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2011; Vol. 34 (6), pp. 810-2. - Publication Year :
- 2011
-
Abstract
- Gastric proton pump (H⁺, K⁺-ATPase) secretes H⁺ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl⁻- and K⁺-transporting proteins are required. Recent our studies have demonstrated that K⁺-Cl⁻ cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na⁺, K⁺-ATPase in the basolateral membrane, and KCC4 is associated with H⁺, K⁺-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 21628876
- Full Text :
- https://doi.org/10.1248/bpb.34.810