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Invariant NKT cells are required for airway inflammation induced by environmental antigens.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2011 Jun 06; Vol. 208 (6), pp. 1151-62. Date of Electronic Publication: 2011 May 30. - Publication Year :
- 2011
-
Abstract
- Invariant NKT cells (iNKT cells) are a unique subset of T lymphocytes that rapidly carry out effector functions. In this study, we report that a majority of sterile house dust extracts (HDEs) tested contained antigens capable of activating mouse and human iNKT cells. HDEs had adjuvant-like properties in an ovalbumin (OVA)-induced asthma model, which were dependent on Vα14i NKT cells, as vaccinated animals deficient for iNKT cells displayed significantly attenuated immune responses and airway inflammation. Furthermore, the administration of HDEs together with OVA mutually augmented the synthesis of cytokines by Vα14i NKT cells and by conventional CD4(+) T cells in the lung, demonstrating a profound immune response synergy for both Th2 cytokines and IL-17A. These data demonstrate that iNKT cell antigens are far more widely dispersed in the environment than previously anticipated. Furthermore, as the antigenic activity in different houses varied greatly, they further suggest that iNKT cell responses to ambient antigens, particular to certain environments, might promote sensitization to conventional respiratory allergens.
- Subjects :
- Animals
CD4-Positive T-Lymphocytes cytology
Cytokines metabolism
Dendritic Cells cytology
Environment
Granulocyte-Macrophage Colony-Stimulating Factor metabolism
Humans
Hybridomas metabolism
Inflammation
Interleukin-17 metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Ovalbumin metabolism
Receptors, Antigen, T-Cell metabolism
Th2 Cells cytology
Allergens pharmacology
Natural Killer T-Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 208
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21624935
- Full Text :
- https://doi.org/10.1084/jem.20102229