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International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations.
- Source :
-
Vaccine [Vaccine] 2011 Jul 18; Vol. 29 (32), pp. 5203-9. Date of Electronic Publication: 2011 May 25. - Publication Year :
- 2011
-
Abstract
- Recombinant adenovirus serotype 5 (rAd5) vaccine vectors for HIV-1 and other pathogens have been shown to be limited by high titers of Ad5 neutralizing antibodies (NAbs) in the developing world. Alternative serotype rAd vectors have therefore been constructed. Here we report Ad5, Ad26, Ad35, and Ad48 NAb titers in 4381 individuals from North America, South America, sub-Saharan Africa, and Southeast Asia. As expected, Ad5 NAb titers were both frequent and high magnitude in sub-Saharan Africa and Southeast Asia. In contrast, Ad35 NAb titers proved infrequent and low in all regions studied, and Ad48 NAbs were rare in all regions except East Africa. Ad26 NAbs were moderately common in adults in sub-Saharan Africa and Southeast Asia, but Ad26 NAb titers proved markedly lower than Ad5 NAb titers in all regions, and these relatively low Ad26 NAb titers did not detectably suppress the immunogenicity of 4×10(10)vp of a rAd26-Gag/Pol/Env/Nef vaccine in rhesus monkeys. These data inform the clinical development of alternative serotype rAd vaccine vectors in the developing world.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- AIDS Vaccines immunology
Adenoviridae isolation & purification
Adenoviridae Infections blood
Adenoviridae Infections virology
Adolescent
Adult
Animals
Antibodies, Viral blood
Child
HIV-1 immunology
Humans
Infant
Macaca mulatta immunology
Vaccines, Synthetic immunology
Young Adult
Adenoviridae immunology
Adenoviridae Infections epidemiology
Adenoviridae Infections immunology
Antibodies, Viral immunology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 29
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 21619905
- Full Text :
- https://doi.org/10.1016/j.vaccine.2011.05.025