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Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2011 Jul 07; Vol. 9 (13), pp. 4760-2. Date of Electronic Publication: 2011 May 26. - Publication Year :
- 2011
-
Abstract
- We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled d-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.
- Subjects :
- Carbocyanines chemical synthesis
Carbocyanines metabolism
Cell Line, Tumor
Cell Membrane Permeability
Deoxyglucose analogs & derivatives
Deoxyglucose analysis
Deoxyglucose chemistry
Fluorescent Dyes chemical synthesis
Fluorescent Dyes metabolism
Glucosamine analysis
Glucosamine chemical synthesis
Glucosamine metabolism
Humans
Indoles analysis
Indoles chemistry
Molecular Structure
Neoplasms metabolism
Spectroscopy, Near-Infrared
Carbocyanines analysis
Fluorescent Dyes analysis
Glucosamine analogs & derivatives
Neoplasms chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 9
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21614387
- Full Text :
- https://doi.org/10.1039/c1ob05519d