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Nisin F, intraperitoneally injected, may have a stabilizing effect on the bacterial population in the gastro-intestinal tract, as determined in a preliminary study with mice as model.
- Source :
-
Letters in applied microbiology [Lett Appl Microbiol] 2011 Aug; Vol. 53 (2), pp. 198-201. Date of Electronic Publication: 2011 Jun 09. - Publication Year :
- 2011
-
Abstract
- Aims: To determine if nisin F has an effect on the bacterial population in the gastro-intestinal tract.<br />Methods and Results: Six male C57BL/6 mice were intraperitoneally injected with 200 μl sterile saline and six with nisin F (200 μl, equivalent to 640 arbitrary units). Fecal samples were collected before injection and 8, 24 and 48 h after injection, and the bacteria amplified by PCR-DGGE using 16S rDNA primers. The composition of the bacterial population in the gastro-intestinal tract (GIT) of mice that were injected with saline changed during 48 h, whereas the bacterial population in the GIT remained relatively unchanged in animals injected with nisin F.<br />Conclusions: These results suggest that nisin F inhibits the growth of specific bacteria in the GIT within the first 4 h. Furthermore, the species remained repressed for at least 44 h after one intraperitoneal injection with nisin F.<br />Significance and Impact of the Study: This is the first report suggesting that nisin F may have a stabilizing effect on the bacterial population in the gastro-intestinal tract.<br /> (© 2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.)
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Bacteriocins administration & dosage
Feces microbiology
Injections, Intraperitoneal
Male
Mice
Mice, Inbred C57BL
Nisin administration & dosage
Anti-Bacterial Agents pharmacology
Bacteria drug effects
Bacteriocins pharmacology
Gastrointestinal Tract microbiology
Nisin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1472-765X
- Volume :
- 53
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Letters in applied microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 21609345
- Full Text :
- https://doi.org/10.1111/j.1472-765X.2011.03091.x