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daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase.
- Source :
-
Cell [Cell] 1990 May 18; Vol. 61 (4), pp. 635-45. - Publication Year :
- 1990
-
Abstract
- The dauer larva is a developmentally arrested, non-feeding dispersal stage normally formed in response to overcrowding and limited food. The daf-1 gene specifies an intermediate step in a hierarchy of genes thought to specify a pathway for neural transduction of environmental cues. Mutations in daf-1 result in constitutive formation of dauer larvae even in abundant food. This gene has been cloned by Tc1-transposon tagging, and it appears to encode a new class of serine/threonine kinase. A daf-1 probe detects a 2.5 kb mRNA of low abundance, and the DNA sequence indicates that the gene encodes a 669 amino acid protein, with a putative transmembrane domain and a C-terminal protein kinase domain most closely related to the cytosolic, raf proto-oncogene family. Hence, the daf-1 product appears to be a cell-surface receptor required for transduction of environmental signals into an appropriate developmental response.
- Subjects :
- Alleles
Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis growth & development
Cloning, Molecular
DNA Transposable Elements
Larva growth & development
Molecular Sequence Data
Mutation
Restriction Mapping
Sequence Homology, Nucleic Acid
Transcription, Genetic
Caenorhabditis genetics
Caenorhabditis elegans Proteins
Genes
Protein Kinases genetics
Receptors, Cell Surface genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0092-8674
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 2160853
- Full Text :
- https://doi.org/10.1016/0092-8674(90)90475-t