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Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease.
- Source :
-
Inflammatory bowel diseases [Inflamm Bowel Dis] 2012 Feb; Vol. 18 (2), pp. 372-90. Date of Electronic Publication: 2011 May 20. - Publication Year :
- 2012
-
Abstract
- The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated.<br /> (Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.)
- Subjects :
- Animals
Bacteria classification
Bacteria genetics
Diet
Escherichia coli Infections immunology
Feces microbiology
Female
Gastrointestinal Tract immunology
Humans
Inflammatory Bowel Diseases surgery
Metabolome
Metagenomics
Mice
Mycobacterium avium subsp. paratuberculosis immunology
Phylogeny
Proteomics
Rats
Transcriptome
Zebrafish genetics
Zebrafish immunology
Zebrafish microbiology
Gastrointestinal Tract microbiology
Inflammatory Bowel Diseases microbiology
Metagenome immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4844
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Inflammatory bowel diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21604329
- Full Text :
- https://doi.org/10.1002/ibd.21751