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Usefulness of plasma galectin-3 levels in systolic heart failure to predict renal insufficiency and survival.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2011 Aug 01; Vol. 108 (3), pp. 385-90. Date of Electronic Publication: 2011 May 19. - Publication Year :
- 2011
-
Abstract
- Galectin-3 plays an important role in fibroblast activation and fibrosis in animal models. Increased galectin-3 levels are associated with poor long-term survival in heart failure (HF). We examined the relation between plasma galectin-3 levels and myocardial indexes of systolic HF. We measured plasma galectin-3 in 133 subjects with chronic HF and 45 with advanced decompensated HF using echocardiographic and hemodynamic evaluations. In the chronic HF cohort, median plasma galectin-3 level was 13.9 ng/ml (interquartile range 12.1 to 16.9). Higher galectin-3 was associated with more advanced age (r = 0.22, p = 0.010), poor renal function (estimated glomerular filtration rate, r = -0.24, p = 0.007; cystatin C, r = 0.38, p <0.0001) and predicted all-cause mortality (hazard ratio 1.86, 95% confidence interval 1.36 to 2.54, p <0.001). In multivariate analysis, galectin-3 remained an independent predictor of all-cause mortality after adjusting for age, estimated glomerular filtration rate, left ventricular (LV) ejection fraction, and mitral early diastolic myocardial relaxation velocity at septal mitral annulus (hazard ratio 1.94, 95% confidence interval 1.30 to 2.91, p = 0.001). However, galectin-3 did not predict the combined end point of all-cause mortality, cardiac transplantation, or HF hospitalization (p >0.05). Furthermore, there were no relations between galectin-3 and LV end-diastolic volume index (r = -0.05, p = 0.61), LV ejection fraction (r = 0.10, p = 0.25), or LV diastolic function (mitral early diastolic myocardial relaxation velocity at septal mitral annulus, r = 0.06, p = 0.52; left atrial volume index, r = 0.08, p = 0.41). In the advanced decompensated HF cohort, we did not observe any relation between galectin-3 and echocardiographic or hemodynamic indexes. In conclusion, high plasma galectin-3 levels were associated with renal insufficiency and poorer survival in patients with chronic systolic HF. However, we did not observe a relation between galectin-3 and echocardiographic or hemodynamic indexes.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Age Factors
Aged
Chronic Disease
Cohort Studies
Echocardiography, Doppler
Female
Follow-Up Studies
Glomerular Filtration Rate physiology
Heart Failure, Systolic diagnostic imaging
Heart Failure, Systolic mortality
Hemodynamics physiology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Reference Values
Renal Insufficiency diagnostic imaging
Renal Insufficiency mortality
Survival Rate
Ventricular Dysfunction, Left blood
Ventricular Dysfunction, Left diagnostic imaging
Ventricular Dysfunction, Left mortality
Galectin 3 blood
Heart Failure, Systolic blood
Renal Insufficiency blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1913
- Volume :
- 108
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 21600537
- Full Text :
- https://doi.org/10.1016/j.amjcard.2011.03.056