[Metabolism of mangiferin by human intestinal bacteria in vitro].

Authors :: Huang H
Tan Z
Deng J
Liang Q
Nong Y
Song N
Source :: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2011 Feb; Vol. 36 (4), pp. 443-5.
Publication Year :: 2011
Abstract: Objective: To study the metabolism of mangiferin by human intestinal bacteria in vitro.<br />Method: Human intestinal bacteria and mangiferin were incubated under anaerobic conditions in vitro. The metabolite was separated and purified by D101 macroporous resin column and preparation high performance liquid chromatography, and its structure was identified by MS and NMR.<br />Result: After 12 h incubation with human intestinal bacteria, the content of mangiferin metabolite reached the maximum, and it was determined as 1, 3, 6, 7-tetrahydroxyxanthen by MS and NMR.<br />Conclusion: Mangiferin can be metabolized in vitro by human intestinal bacteria into its aglycone (1, 3, 6, 7-tetrahydroxyxanthen).

Subjects :: Chromatography, High Pressure Liquid
Humans
Bacteria metabolism
Intestines microbiology
Xanthones metabolism

Language :: Chinese
ISSN :: 1001-5302
Volume :: 36
Issue :: 4
Database :: MEDLINE
Journal :: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Publication Type :: Academic Journal
Accession number :: 21598537

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