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Bisphosphonate treatment delays stress fracture remodeling in the rat ulna.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2011 Dec; Vol. 29 (12), pp. 1827-33. Date of Electronic Publication: 2011 May 19. - Publication Year :
- 2011
-
Abstract
- Because bisphosphonates (BPs) are potent inhibitors of bone resorption, we hypothesized that they would retard direct remodeling of stress fractures. The aim of this study was to determine the effect of risedronate on direct remodeling and woven bone callus formation following stress fracture formation in the rat ulna. In 135 adult female Wistar rats, cyclic loading of the ulna created stress fractures. Rats were treated daily with oral saline, or risedronate at 0.1 or 1.0 mg/kg. From each bone, histomorphometry was performed on sections stained with toluidine blue at a standard level along the fracture. The high dose of risedronate caused a significant decrease in the percentage of repaired stress fracture and bone resorption along the stress fracture line at 6 and 10 weeks after loading (p < 0.05). At this dose, intracortical resorption was significantly reduced at 10 weeks after loading and intracortical new bone area was significantly reduced at 6 and 10 weeks. Woven bone formation and consolidation phases of stress fracture repair were not affected by low or high doses of risedronate. In conclusion, high dose bisphosphonate treatment impaired healing of a large stress fracture line by reducing the volume of bone resorbed and replaced during remodeling. We also confirmed that periosteal callus formation was not adversely affected by risedronate treatment.<br /> (Copyright © 2011 Orthopaedic Research Society.)
- Subjects :
- Animals
Bony Callus drug effects
Diaphyses drug effects
Diaphyses injuries
Diphosphonates pharmacology
Dose-Response Relationship, Drug
Etidronic Acid pharmacology
Female
Periosteum drug effects
Rats
Rats, Wistar
Risedronic Acid
Bone Density Conservation Agents pharmacology
Bone Remodeling drug effects
Etidronic Acid analogs & derivatives
Fractures, Stress drug therapy
Ulna Fractures drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1554-527X
- Volume :
- 29
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 21598308
- Full Text :
- https://doi.org/10.1002/jor.21464