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[Analysis of the mechanism of the stress-protective action of delta sleep-inducing peptide].
- Source :
-
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1990 Jan; Vol. 109 (1), pp. 46-7. - Publication Year :
- 1990
-
Abstract
- By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization. The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only. The authors propose, that stress-protective action of DSIP is realized with the involvements of the hypothalamo-pituitary-adrenal gland system.
- Subjects :
- Adrenal Glands drug effects
Adrenocorticotropic Hormone blood
Animals
Corticosterone blood
Immobilization
Insulin blood
Male
Radioimmunoassay
Rats
Stress, Physiological physiopathology
Time Factors
beta-Endorphin blood
Adrenal Glands analysis
Brain Chemistry drug effects
Delta Sleep-Inducing Peptide pharmacology
Enkephalin, Methionine analysis
Stress, Physiological prevention & control
Subjects
Details
- Language :
- Russian
- ISSN :
- 0365-9615
- Volume :
- 109
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biulleten' eksperimental'noi biologii i meditsiny
- Publication Type :
- Academic Journal
- Accession number :
- 2159352