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A tick-borne encephalitis virus vaccine based on the European prototype strain induces broadly reactive cross-neutralizing antibodies in humans.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2011 Jun 01; Vol. 203 (11), pp. 1556-64. - Publication Year :
- 2011
-
Abstract
- After vaccination of humans with tick-borne encephalitis virus (TBEV) vaccine, the extent of cross-neutralization between viruses of the European, Far Eastern, and Siberian subtypes of TBEV and Omsk hemorrhagic fever virus (OHFV) was analyzed. Hybrid viruses that encode the TBEV surface proteins for representative viruses within all subtypes, and OHFV, were constructed using the West Nile virus (WNV) backbone as vector. These viruses allow for unbiased head-to-head comparison in neutralization assays because they exhibit the antigenic characteristics of the TBEV strains from which the surface proteins were derived and showed equivalent biologic properties in cell culture. Human serum samples derived from a TBEV vaccine trial were analyzed and revealed comparable neutralizing antibody titers against European, Far Eastern, and Siberian subtype viruses, indicating equally potent cross-protection against these TBEV strains and a somewhat reduced but still protective neutralization capacity against more distantly related viruses, such as OHFV.
- Subjects :
- Adolescent
Adult
Aged
Amino Acid Sequence
Analysis of Variance
Animals
Antibodies, Neutralizing blood
Antibodies, Viral biosynthesis
Antibodies, Viral blood
Cell Line, Tumor
Chlorocebus aethiops
Cloning, Molecular
Encephalitis Viruses, Tick-Borne genetics
Encephalitis Viruses, Tick-Borne growth & development
Encephalitis, Tick-Borne blood
Encephalitis, Tick-Borne immunology
Encephalitis, Tick-Borne prevention & control
Humans
Kinetics
Middle Aged
Molecular Sequence Data
Neutralization Tests
Phenotype
Sequence Alignment
Vero Cells
Viral Vaccines genetics
Virus Cultivation
West Nile virus genetics
Young Adult
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
Cross Reactions immunology
Encephalitis Viruses, Tick-Borne immunology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 203
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21592984
- Full Text :
- https://doi.org/10.1093/infdis/jir122